Effect of propofol-based total intravenous anesthesia on postoperative cognitive function and sleep quality in elderly patients.

PURPOSE This study aimed to observe the effect of propofol-based total intravenous anesthesia (TIVA) on postoperative cognitive function and sleep quality in elderly patients. METHODS From Aug 2019 to Aug 2020, 130 cases of elderly patients who underwent abdominal surgery in The Third Hospital of Hebei Medical University were enrolled in this study. All participants were randomly divided into TIVA group (n=65, receiving Propofol-based ITVA) and control group (n=65, receiving inhaled of sevoflurane anesthesia). Intraoperative indicators were recorded in both groups. The cognitive function, sleep quality, urine melatonin sulfate, free cortisol, S-100 β protein, and interleukin-6 (IL-6) levels were compared at different times. RESULTS On 1, 3, 7 and 15 days after operation, the cognitive function of the TIVA group was better than that of the control group, with statistically significance (P 0.05). On 1, 3, 7 and 15 days after surgery, cortisol and IL-6 in the TIVA group were lower than those of the control group, and melatonin was higher than that of the control group (P < 0.05, respectively). On 1, 3, and 7 days after operation, the S-100 β protein in the TIVA group was lower than that in the control group (P < 0.05, respectively). CONCLUSION Propofol-based ITVA has little effect on the cognitive function and sleep quality of elderly patients after surgery, and it is worthy of clinical application.