Exercise intensity and glycaemic control : the role of redox status and redox-sensitive protein kinase signalling in humans
2017
Physical inactivity and obesity are associated with elevated systemic oxidative
stress and the activation of JNK, p38 MAPK, NF-κB, and protein kinase C (PKC)
signalling pathways in skeletal muscle. Sustained activation of these stress and
mitogen activated protein kinase (SAPK) pathways are associated with impaired
glycaemic control, and the development and progression of cardiometabolic
disease. Paradoxically, acute exercise also increases oxidative stress and SAPK
signalling, yet glycaemic control and skeletal muscle function are enhanced.
Research now supports a role for the transient induction of oxidative stress and
associated activation of SAPK signalling in the physiological response and
adaptation to acute exercise and exercise training. High-intensity interval
exercise (HIIE) is a potent exercise stimulus for the improvement of metabolic
health and skeletal muscle adaption, however the effect of HIIE on oxidative
stress and SAPK signalling is unclear. The aims of this thesis were to explore the
effect of HIIE on glycaemic control, exercise-induced oxidative stress, and
skeletal muscle SAPK signalling, in a series of independent but related studies.
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