The Impact of CMS SEP-1 Core Measure Implementation on Antibacterial Utilization: a retrospective multicenter longitudinal cohort study with interrupted time-series analysis.

Background The impact of the U.S. Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock: Management Bundle (SEP-1) Core Measure on overall antibacterial utilization is unknown. Methods We performed a retrospective multicenter longitudinal cohort study with interrupted time series analysis to determine the impact of SEP-1 implementation on antibacterial utilization and patient outcomes. All adult patients admitted to 26 hospitals between October 1, 2014, and September 30, 2015 (the "SEP-1 preparation period") and between November 1, 2015, and October 31, 2016 (the "SEP-1 implementation period") were evaluated for inclusion.The primary outcome was total antibacterial utilization measured as days of therapy (DOT) per 1,000 patient days. Results The study cohort included 701,055 eligible patient admissions and 4.2 million patient days. Overall antibacterial utilization increased 2% each month during SEP-1 preparation (RR=1.02 per month [95% CI 1.00-1.04]; p=0.02). Cumulatively, the mean monthly DOT/1,000 patient-days increased 24.4% [95% CI 18.0, 38.8] over the entire study period (October 2014-October 2016). The rate of sepsis diagnosis/1,000 patients increased 2% each month during SEP-1 preparation (RR=1.02 per month [95% CI 1.00-1.04]; p=0.04). The rate of all-cause mortality/1,000 patients decreased during the study period (SEP-1 preparation RR=0.95 [0.92-0.98]; p=0.001 and SEP-1 implementation RR=0.98 [95% CI 0.97-1.00]; p=0.01). Cumulatively, the monthly mean all-cause mortality/1,000 patients declined 38.5% [95% CI 25.9, 48.0] over the study period. Conclusions Announcement and implementation of the CMS SEP-1 process measure was associated with increased diagnosis of sepsis and antibacterial utilization and decreased mortality among hospitalized patients.