Experience from Clinical Trials with Fertility Control Vaccines
2009
Three vaccines for hCG have undergone Phase I Clinical trial but only one HSD-hCG vaccine went through Phase II efficacy trials demonstrating its ability to prevent pregnancy without impairment of ovulation and derangement of menstrual cycles and bleeding profiles. One semi-synthetic vaccine against LHRH has had Phase I/II clinical trials in India and Austria in 28 patients of carcinoma prostate. In this chapter, highlights of these vaccines are presented and issues related to clinical trials are discussed.
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