Study on clinical and laboratory diagnostic of Lyme disease in dogs after experimental infection.
2012
Experimental infection was done on 13 dogs, with B. burgdorferi s.l., in the
epitzootiological area where Lyme disease in dogs and humans is present.
Prior to the experimental infection, dogs in the experiment had no contact
with B. burgdorferi, and they were kept in isolation. Serological methods
used in the study were complement fixation and ELISA test. Biochemical blood
analysis was done, also. The experimental infection of dogs was done with a
referent ATCC B. burgdorferi s.l. culture, and with the isolates of B.
burgdorferi s.l. previousely gained from Ixodes ricinus ticks collected on
selected locations of the observed region in the northern part of Serbia
(Vojvodina province). After the experimental infection, clinical symptoms
were not seen in dogs and positive serological results were found in 70% of
experimentally infected dogs. Immunodiagnostic criteria for the diagnosis of
Lyme disease in dogs are established. In dogs without clinical symptoms for
Lyme disease, when clarifying the laboratory results, one must have in mind
the epizootiological situation of the region and also the possibility of
former contact of the dog with B. burgdorferi s.l. For epizootiological
surveys, CF can be used as an approximate screening method, with obligatory
conformation with ELISA in the case of positive findings.
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