Polyoxometalate cobalt–gatifloxacin complex with DNA binding and antibacterial activity
2014
An unusual inorganic–organic antibacterial complex based on polyoxometalates (POMs) and the cobalt–gatifloxacin (GT), [CoII(C19FH22N3O4)3][C19FH23N3O4][HSiW12O40]·23H2O (1), has been synthesized. Single-crystal structural analysis shows that 1 represents for the first time an unusual tripodal coordination style with three GT molecules coordinating to cobalt(II) by six carboxylate and hydroxyl oxygens. The biological activity of 1 has been evaluated by investigating its binding ability to calf thymus DNA (CT-DNA). UV spectrum study of 1 has shown that it can bind to CT-DNA by intercalation. The DNA-binding constant Kb was 9.6 × 104 M L−1, higher than that of pure GT, 3.8 × 104 M L−1. Furthermore, the antibacterial activities of 1 were tested against Staphylococcus aureus and Escherichia coli, respectively, and have shown slightly lower antibacterial activity than that of free GT at the same mass concentration. If the GT component in the complexes was controlled at the same molar concentration, 1 generates ...
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