A Randomized Double-Blind Study Comparing Intradermal Anesthetic Tolerability, Efficacy, and Cost-Effectiveness of Lidocaine, Buffered Lidocaine, and Bacteriostatic Normal Saline for Peripheral Intravenous Insertion

In this double-blind study, 256 surgical patients meeting eligibility criteria were randomized in a 1:1:1 ratio to 1 of the 3 intradermal injection groups prior to intravenous (IV) line insertion (Group 1 = 1% lidocaine, Group 2 = 1% buffered lidocaine, and Group 3 = bacteriostatic normal saline wit