Metre-long cell-laden microfibres exhibit tissue morphologies and functions

Macroscopically long, cell-encapsulating, core–shell hydrogel microfibres that can be assembled into macroscopic cellular constructs by weaving and reeling are shown to reconstitute intrinsic morphologies and functions of living tissues. When transplanted into the subrenal capsular space of diabetic mice, the microfibres normalize blood glucose concentrations for about two weeks and can later be removed.