Genetic deletion of S100A9 fails to abrogate psoriasiform inflammation in the KC-Tie2 mouse model due to IL-12/23 compensation. (CAM5P.237)

The proinflammatory proteins S100A8/9 are purported to play a pathogenic role in psoriasis. A recent report showed genetic deletion of S100A9 strongly attenuated ear skin inflammation in the K5-JunB:Jun mouse and imiquimod skin inflammation models. We previously reported increased expression of S100A8/9 (>135-fold; P