Comparison of CA 125 alone and risk of ovarian malignancy algorithm (ROMA) in patients with adnexal mass: A multicenter study

Abstract Background: This multicenter study aimed to evaluate the performance of CA 125 and risk of ovarian malignancy algorithm (ROMA) in differentiating epithelial ovarian cancer (EOC) from benign adnexal mass. Methods: We consecutively enrolled 782 patients referred to tertiary hospitals with adnexal mass requiring surgical treatment. A total of 322 patients with benign adnexal disease and 327 patients with EOC were included in the analysis. Results: Using reference cut-off values in premenopausal women, ROMA had better specificity (0.926 vs 0.787, P