Effect of Hypothyroidism on Unruptured Cerebral Aneurysm Dimensions and Endovascular Coiling Outcome (P6.017)

Objective: Effect of Hypothyroidism on Unruptured Cerebral Aneurysm Dimensions and Endovascular Coiling Outcome Background: In a previous case-control study, we found significant association of history of hypothyroidism with occurrence of unruptured cerebral aneurysm in women within our patient cohort. Hypothyroidism has been shown to cause mucopolysaccharide deposition with association to blood vessel wall weakening and aneurysm formation in some case reports. We hypothesized that women with hypothyroidism may also have larger aneurysm size. Methods: We performed a retrospective cohort study of consecutive female patients with cerebral aneurysm receiving 3-vessel cerebral angiography at our tertiary-care academic medical center. Exclusion criteria included any ruptured aneurysm. We compared aneurysm dimensions measured from digital subtraction angiography between the group with hypothyroidism and without. multivariate analysis between the groups to control for age, hypertension, diabetes, hyperlipidemia, smoking, alcohol or drug abuse, and family history of aneurysm. Endovascular coiling outcome was recorded as Raymond-Roy Occlusion Classification (RROC) and recanalization on follow-up angiography Results: From 2008 through 2013, 178 female patients with cerebral aneurysms were identified. 34 patients had hypothyroidism. Aneurysms dimension in the hypothyroidism group and control group shows significant different in neck sizes 5.4±0.5 vs 4.2±0.2mm (p=0.01). The mean of other dimensions were, height 10.4±1.2 vs 8.3±0.4mm (p=0.059), maximal dimension 10.6±1.1 vs 9.3±0.5mm (p=0.2), and aspect ratio 2±0.1 vs 2±0.2. No significant difference was noted in RROC and subsequent recanalization. Conclusions: Hypothyroidism has a significant association with cerebral aneurysm neck size in women and trend to higher aneurysm height and maximal dimension which may link to higher risk of rupture. There was no significant difference in endovascular coiling outcome. Disclosure: Dr. Atchaneeyasakul has nothing to disclose. Dr. Tipirneni has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Khandelwal has nothing to disclose. Dr. Delgado has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Dharmadhikari has nothing to disclose. Dr. Ambekar has nothing to disclose. Dr. Snelling has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member.