Prospective Registry of Multiplex Testing (PROMPT): Feasible and sustainable.

1543Background: Prospective Registry of Multiplex Testing (PROMPT) is an online registry for individuals who completed multiplex panel testing for cancer susceptibility. The overall objective of this registry is to ascertain families to allow penetrance calculations for mutations in less characterized genes. Methods: Since September 2014, health care providers and commercial laboratories have provided PROMPT information to eligible participants and ordering providers with the test results. The PROMPT registry has self-enrolled those with pathogenic mutations and variants of unknown significance (VUS) in cancer susceptibility genes. Registrants consent to full participation (FP), permitting study investigators to have contact information, or partial participation (PP), with de-identified information only. In 2016, we expanded to Phase II, targeting enrollment by genes of interest for family co-segregation, and collecting additional risk factor data and saliva samples. Results: Over 4500 individuals have en...