Nanocomposite of PVA/PVP blend incorporated by copper oxide nanoparticles via nanosecond laser ablation for antibacterial activity enhancement

This work makes an investigation of Polyvinyl Alcohol (PVA)/Polyvinyl Pyrrolidone (PVP) composite scattered by copper oxide nanoparticles. Spectroscopic techniques have been utilized for studying the mechanism of the reaction between PVA/PVP and CuO NPs. Cell viability and antibacterial assessment are used for investigating the antibacterial activity of nanocomposite systems. XRD and FTIR-ATR approved the complexation and miscibility between PVA, PVP, and CuO NPs UV–Vis spectra approved the embedding of CuO NPs into PVA/PVP by the appearance of an additional peak at 336 nm. Optical parameters and bandgap calculation indicate that CuO NPs decrease the crystallinity of the nanocomposite system. DSC measurements were also studied to reveal the thermal stability of the prepared sample. The inhibition zone values of E. coli and S. aureus microorganisms increased by increasing the CuO NPs ratio in PVA/PVP to 18.5 ± 0.5 and 20.4 ± 6.0. The responses of the fibroblast cell line to the synthesized nanocomposites showed the capacity of PVA/PVP/CuO NPs nanocomposite to be recommended for biomedical applications.