Abstract PS11-19: Metformin improves the survival in Chinese early invasive breast cancer patients with type 2 diabetes mellitus

Objective: The purpose of this retrospective study was to investigate the effect of metformin on the survival of Chinese breast cancer patients with type 2 diabetes mellitus (T2DM) after surgery. Methods: A total of 3,553 primary breast cancer patients who underwent surgery from January 2010 to December 2013 was enrolled in this study. The patients were divided as metformin group (312 cases), insulin group (79 cases) and non-diabetes group (3139 cases) according medication treatment. The median follow-up time was 85 months. Overall survival (OS) and disease-free survival (DFS) after tumor removal were estimated with the Kaplan-Meier method followed by a log-rank test for evaluating three groups differences. Multivariate Cox proportional hazards regression model was applied to estimate the relationship between metformin and prognosis of breast cancer patients with T2DM. Results: Clinical and pathological features of three group patients were matched. There was a significant survival difference among metformin group, insulin group and non-diabetes group, 5-year OS was 97.1%, 73.3%, 87.3%, and 5-year DFS was 96.1%, 73.0%, 85.8% respectively (P Citation Format: Tianli Hui, Chao Shang, Zhenchuan Song. Metformin improves the survival in Chinese early invasive breast cancer patients with type 2 diabetes mellitus [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS11-19.