Hydrogen Peroxide Inducible JAK3 Covalent Inhibitor: Prodrug for the Treatment of RA with Enhanced Safety Profile

Qi-Chao Bao,Liangying Zhang,Nan Wang,Brian Gabet,Weikang Yang,Xingyang Gao,Qidong You,Zheng-Yu Jiang

Hydrogen Peroxide Inducible JAK3 Covalent Inhibitor: Prodrug for the Treatment of RA with Enhanced Safety Profile

2020

Qi-Chao Bao
Liangying Zhang
Nan Wang
Brian Gabet
Weikang Yang
Xingyang Gao
Qidong You
Zheng-Yu Jiang

Selective inhibition of Janus kinases (JAKs) is an arising strategy in drug discovery. Covalent inhibitors targeting a unique cysteine in JAK3 exhibit ultraselectivity among JAK family members. How...

Keywords:

Covalent bond
Biochemistry
Chemistry
safety profile
Janus kinase
Prodrug
Cysteine
Hydrogen peroxide
selective inhibition
Drug discovery

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