Model Drug Release from Potato Starch-Starch Glycolate Microparticles and Films with and without Incorporated Nano-SiO 2

Mixing potato starch (PSS) with sodium starch glycolate (SSG) and silica nanoparticles (SiO2) substantially controls its swelling and mechanical behavior. Therefore, starch-starch glycolate-based delivery systems may be suitable for regulated model drug delivery. This work aimed to examine the release of dye from starch micro-particles and films as a mimic study for the drug release from an excipient. Starch film was prepared in vitro using glycerol as a plasticizing agent in aqueous gelatinous solution containing different amounts of SSG in the presence and absence of SiO2. UV-vis spectroscopic technique was used to investigate the release kinetics of a model drug-like compound (Crystal violet, CV) in phosphate buffer solution (PBS) pH 7.4 at 37 oC. The swelling and folding strength of films have showed the different sensitivities of the films to SSG content and incorporation of SiO2. It has been determined that SSG's cross-linking capability plays a critical role in starch's mechanical and rheological properties. Release of cationic drug across the polymeric films was significantly higher than that of the physical mixtures of CV in PSS-SSG microparticles. A higher release percentage was detected for PSE-Si-CV than that of PSE-Si-CV-SSG1%. The mechanism for the release of drugs was found to obey quasi-Fickian and non-Fickian diffusion mechanism for the PSS-Si-CV and PSS-Si-CV-SSG1% films.