Increased tumor purity and improved biomarker detection using precision needle punch enrichment of pathology specimen paraffin blocks: Method validation and implementation in a prospective clinical trial.

Jonathan Keith Killian,Chris Wright,Lindsay Chan,Natalie Danziger,Julia Andrea Elvin,Jo-Anne Vergilio,Douglas I. Lin,Erik A. Williams,Shakti H. Ramkissoon,Eric Allan Severson,Amanda Hemmerich,Daniel Duncan,Claire I. Edgerly,Julie Tse,Kimberly McGregor,Alexa Betzig Schrock,Brian M. Alexander,Jeffrey S. Ross,Mary W. Redman,Roy S. Herbst

Increased tumor purity and improved biomarker detection using precision needle punch enrichment of pathology specimen paraffin blocks: Method validation and implementation in a prospective clinical trial.

2020

3622Background: While many sequencing assays may be geared for short variants (SV), more complex biomarkers such as genomic loss of heterozygosity (gLOH) score, also referred to as homologous recom...

Keywords:

Pathology
Biomarker (medicine)
Clinical trial
Medicine

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