Increased serum levels of hepcidin and C-reactive protein in patients with brucellosis

Background: Increased serum level of C-reactive protein (CRP) as a classic acute phase protein has commonly been reported in acute brucellosis. Hepcidin is also an acute phase protein and has a critical role in host defense. The aim of this study was to compare the level of hepcidin and CRP in patients with brucellosis. Methods: All patients with brucellosis referred to Sina Hospital during a 10-month period were included. Serum samples were checked for hepcidin levels in patients and also in the control group. Information on demographic and clinical characteristics was determined through completion of a questionnaire. Results: A total of 42 patients with brucellosis and 42 healthy controls were enrolled. The most common symptoms of brucellosis were fever (76) and arthralgia (69). The mean serum level of hepcidin in patients (42.6±11.7 pg/mL) was significantly higher than in the controls (17.3±4.2 pg/mL) (p<0.001). The mean serum levels of CRP in patients and controls were 12.6±12.2 and 3.1±2.4 mg/L, respectively (p=0.001). Conclusions: Increased serum levels of hepcidin in brucellosis can be considered a diagnostic biomarker of inflammation and active disease. Further studies are needed to identify the role of hepcidin as a host defense mechanism in brucellosis.