Application of combined detection of SDF-1, CXCR4 and MVD in evaluating prognosis of patients with multiple myeloma

Objective To investigate the application of combined detection of stromal cell derived factor-1 (SDF-1), chemokine receptor 4 (CXCR4) and microvessel density (MVD) in evaluating the prognosis of patients with multiple myeloma. Methods Seventy-six patients with multiple myeloma in Jincheng General Hospital from April 2015 to June 2018 were selected as study group, and 30 patients with normal bone marrow in the same period were selected as control group. The expression levels of SDF-1, CXCR4 and MVD and their correlations were compared between the two groups. The correlation of age, sex, international staging system (ISS) stage, immunoglobulin typing, SDF-1, CXCR4, MVD with prognosis was analyzed. Results The positive levels of SDF-1 and CXCR4 in study group were significantly higher than those in control group (P<0.05), and the MVD level in study group was also significantly higher than that in control group (P<0.05). The expression of SDF-1 and CXCR4 was positively correlated with MVD level in study group (P<0.05). Analysis of prognostic factors showed that age, ISS stage, immunoglobulin typing, expression of SDF-1 and CXCR4, MVD count could be used as prognostic factors for multiple myeloma. Conclusions SDF-1, CXCR4 and MVD may play positive roles in promoting the development of multiple myeloma, and they are all factors affecting the prognosis. Therefore, the prognosis of patients can be effectively evaluated by detecting the levels of SDF-1, CXCR4 and MVD. Key words: Stromal cell derived factor-1; Chemokine receptor 4; Microvessel density; Combined detection; Multiple myeloma; prognosis