Tumor markers as predictors of outcome in patients with advanced esophagogastric adenocarcinoma (EGA) treated with chemotherapy.

e15061 Background: The clinical usefulness of tumor markers (TM) as predictors of treatment outcome in advanced EGA has been poorly defined. The aim of this study was to evaluate the prognostic significance of serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA19-9) and cancer antigen 125 (CA125) levels in these patients. Methods: From April 2011 through October 2014, baseline and nadir serum levels of CEA, CA19-9 and CA125 were detected in 67 patients diagnosed with metastatic EGA treated with first line treatment, and TM reduction ratio was calculated. Chemotherapy efficacy was evaluated according to RECIST 1.1, and the relationship between TM response, chemotherapy efficacy, several clinicopathological features, and survival were determined by Cox regression analyses. Results: Data of 67 patients (median age 67 years, range 42-88) were analyzed retrospectively. The most usual histological subtype was diffuse (31.3%); G3 histologic in 20.9%; Her2 overexpression in 22.4%. Fifty-one patients (7...