Correlation Between Tumor-Associated Macrophage and Inflammatory Factors in Lymphoma Patients

Introduction To study the expression of tumor associated macrophage (TAMs), inflammatory cytokines IL-1β (interleukin-lβ), TNF-α (tumor necrosis factor-α), IL-6 (interleukin 6) and IL-10 (interleukin 10) and its significance in different types of lymphoma in lymph node pathological tissue. Methods 106 cases of clinical pathology specimens of patients were collected from different types and different staging classifications. The expressions of tumor-associated macrophage and interleukin-1β (IL-1β), tumor nec.rosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in lymphoma tissues were detected by immunohistochemical staining; Results Both CD68 and CSF-1R showed high expression in lymphoma tumor tissues. The positive rates of CD68 and CSF-1R in Ⅳ period patients was higher than Ⅱperiod ( P P P P P Conclusion 1.CD68, tumor-associated macrophage phenotype, and CSF-1R were highly expressed in lymphoma tissues 2.The expression of CD68 was positively correlated with inflammatory cytokines. 3.TAMs were involved in tumor inflammatory microenvironment. Funded by Jiangsu Provincial Special Program of Medical Science (BL2012005) Disclosures No relevant conflicts of interest to declare.