Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles
2017
Summary This study investigated the release and proteomic profile of tissue factor microparticles (TFMPs) prospectively (up to 6 months) following a myocardial infarction (MI) in a chronic porcine model to establish their utility in tracking cellular level activities that predict physiologic outcomes. Our animal groups (n = 6 to 8 each) consisted of control, noninfarcted (negative control); infarcted only (positive control); and infarcted animals treated with cardiac resynchronization therapy (CRT) and a β-blocker (BB) (metoprolol succinate). The authors found different protein profiles in TFMPs between the control, infarcted only group, and the CRT + BB treated group with predictive impact on the outward phenotype of pathological remodeling after an MI within and between groups. This novel approach of monitoring cellular level activities by profiling the content of TFMPs has the potential of addressing a shortfall of the current crop of cardiac biomarkers, which is the inability to capture composite molecular changes associated with chronic maladaptive signaling in a spatial and temporal manner.
Keywords:
- Proteomic Profile
- Metoprolol Succinate
- Cardiac resynchronization therapy
- Myocardial infarction
- Pathological
- Tissue factor
- Phenotype
- Cardiac biomarkers
- Internal medicine
- Cardiology
- Medicine
- Surgery
- Proteomic Profiling
- Ischemic cardiomyopathy
- receptor signaling
- Biomedical engineering
- protein content
- Pharmacology
- plasma samples
- Correction
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