Plasmacytoma in the Bilateral Breast

Multiple myeloma (MM) is a B-cell malignancy of neoplastic plasma cells that generally produce a monoclonal immunoglobulin protein. This disease causes clinical symptoms by way of tumor mass effects (pain), cytokine production (anemia) and protein deposition in organs such as kidney and heart. Clinical manifestations of myeloma vary as a result of the heterogeneous biyology and span the entire spectrum from indolent disease to highly aggresive myeloma presenting with extramedullary features[1]. Extraskeletal involvement by MM is well recognized, with involvement of the liver, spleen, kidneys and lymph nodes seen in more than 70% of patients at autopsy[2]. However, breast involvement is rare as part of a MM and only few cases reported[3]. We have described a case of a soft tissue plasmacytoma involving bilateral breast which is a very unusual manifestation of MM.