Evaluation of the ROS inhibiting activity and mitochondrial targeting of phenolic compounds in fibroblast cells model system and enhancement of efficiency by natural deep eutectic solvent (NADES) formulation

Purpose Many phenolics have already been tested for their antioxidant activities using in vitro methods. However, such assays do not consider the complexity of real cellular systems, and most of the phenolics characterized with such assays shows disappointing results when evaluated in cells. Accordingly, there is a need to develop effective screening methods.