Solid-phase synthesis of C-terminal azapeptides†

The solid-phase synthesis of azapeptides possessing a C-terminal aza-residue has been accomplished by a protocol featuring regioselective alkylation of benzhydrylidene-aza-glycinamide and illustrated by the syntheses of [aza-Lys6] growth-hormone-releasing peptide-6 analogs. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.