MMP-13 polymorphism (rs640198) in patients with confirmed CAD
2011
The genetic background that underlies the susceptibility,
occurrence and severity of CAD is still poorly elucidated.
MMP-13 was proposed as another possible candidate for the
NO-mediated prevention of atherosclerosis. The study comprised
1071 consecutive patients, 734 men and 337 women, median age 48
years, with suspected or known CAD referred for coronary
angiography. During the short-term hospitalization the patients
underwent full cardiologic investigation (history, physical
examination, electrocardiography, laboratory examination,
coronary angiography, echocardiography in patients with unclear
diagnosis). The study was approved by the institutional ethics
committee; informed consent of all patients is archived. The
intron G/T polymorphism (rs640198) in MMP-13 gene was detected
by TaqMan SNP genotyping. A significant difference in the
MMP-13 polymorphism was observed between patients with
clinically manifest coronary artery diseases (CAD) compared to
those without the disease (Pg =0. 06, Pa=0.02). As a result of
the multivariate analysis, significant interaction between
MMP-13 polymorphism and the total number of stenoses was
observed when EF LV and HR had been included as dependent
continuous variables (P=0.03, power test = 96%). In detail, the
TT genotype of MMP-13 differs from GG and GT genotypes whose EF
LV gradually drops with higher number of stenoses. The values
of heart rate are more oscillating in patients with the TT
genotype. The TT genotype of MMP-13 polymorphism is associated
with different hemodynamic characteristics compared to the
other genotypes of the polymorphism in patients with coronary
artery disease.
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