Postoperative Analgesic Effects of Parecoxib Sodium Combined with Infraclavicular Brachial Plexus Block on Patients Undergoing Hand Surgery

Objective:To investigate the postoperative analgesic effects of parecoxib sodium combined with infraclavicular brachial plexus block on patients undergoing hand surgery.Methods:One hundred patients undergoing hand surgery were selected and randomly divided into two groups(n=50): the parecoxib sodium group(Group P) and the control group(Group C).After the success of infraclavicular brachial plexus block,patients in Group P were administered one bolus of parecoxib sodium(40mg,diluted by 2mL N.S.) intravenously 15 minutes before the beginning of operation,while those in Group C were injected N.S.by the same volume.VAS(visual analogue scale) was performed at postoperative 6,8,12 and 24 hours respectively,meanwhile,time and VAS to first pain,the number of patients demanded painkiller,time and VAS to first analgesia demanded were recorded and the adverse reactions were observed as well within 24h after operation.Results: The VAS scores at postoperative 8 and 12 hours,the number of patients demanded painkiller,the VAS score to first analgesia demanded were all less in Group P than those in Group C(P0.05),while there was no significant difference in incidence of adverse reactions between the two groups within 24h after operation(P0.05).Conclusions: Parecoxib sodium combined with infraclavicular brachial plexus block is safe and effective on postoperative analgesic effects after hand surgery.Parecoxib sodium could be a good choice of perioperative multimodal analgesia techniques.