Profil évolutif de la drépanocytose SC à Dakar : étude cas-témoin avec la forme SS

Aims: The study aim to describe the epidemiological, cli  nico-biological and evolutionary aspects of SC   sickle cell patients compared to SS sickle cell dis  ease.   Patients and methods : We realized a case-  control study of 12 months duration including 98 ma  jor sickle cell patients (49 SC and 49 SS sickle   cell  patients).  SS  sickle  cell  patients  were  random  ly  selected  according  to  age  and  sex.  Socio-  demographic, clinico-biological and evolutionary da  ta were noted for each patient.   Results  : Mean age   was 24.7 years (5 - 53). Sex ratio was 0.8. Mean nu  mber of transfusions was 0.06 of SC patients and   0.34  for  SS  patients  (p=0.0008).  Mean  number  of  vas  o-occlusive  crisis  per  year  was  2.24  of  SC   patients and 2.37 of SS patients (p=0.3). Mean basi  c hemoglobin level was 10.8 of SC patients and 7.8   of SS patients (p=0.0000). Priapism was found in 2.  04% of SC patients and 4.04% of SS patients   (p=0.3) and acute anemia in 2.04% of SC and 24.48%   of SS patients (p=0.003); 26.53% of SC patients   had a chronic complication compared to 18.36% of SS   patients (p=0.0001).   Conclusion  : This study   shows that SC sickle cell patients are less symptom  atology compared to SS patients, however they   would develop more chronic complications from where   the utility for regular follow-up.