Inhibition of immunity control points in ovarian cancer

Immune checkpoints such as CTLA4 and PD1 and PD2 have significant impact on the immune response through T-cell function modulation. Tumor cells can use this mechanism to avoid immune surveillance through PD-L1 signaling pathway. Currently, the number of tumor immunotherapies is growing, including the application of anti-PDl and anti- PDLl monoclonal antibodies for specific immune response reactivation. Assessment of PD-L1 expression can be used as a potential prognostic biomarker for the efficacy of malignant tumor treatment and its duration as well as an immunotherapy-modulated response predictor. In the field of immunotherapeutic treatment of ovarian cancer, a number of questions remain unclear: how exactly does the pathological immune response develop when these tumors occur, how to identify the most promising tumors for exposure to anti-PDL1 and anti-PDL2 antibodies, which systems to use for the expression of molecules in tissues, which combination drugs with the inclusion of immunotherapy will be most effective and many others. The review provides information already obtained in the search for answers to these questions, and outlines the range of those studies that have yet to be carried out. Keywords: PD-1, PD-L1, immune checkpoints, cancer immunotherapy