MP26-12 NODE-POSITIVE (CN+) UROTHELIAL CARCINOMA OF THE BLADDER TREATED WITH CHEMOTHERAPY AND RADICAL CYSTECTOMY: CLINICAL OUTCOMES AND DEVELOPMENT OF A RISK PREDICTION MODEL

INTRODUCTION AND OBJECTIVES:Clinically node-positive (cN+) bladder cancer is considered Stage IV disease and the mainstay of treatment is chemotherapy. However, a subset of patients undergoes consolidative radical cystectomy (RC). We examined the clinical outcomes of patients with cN+ bladder cancer treated with chemotherapy and RC and developed a risk prediction model to facilitate risk-stratification and management.METHODS:We identified adult patients with cTany cN1-3 cM0 urothelial carcinoma of the bladder treated with systemic chemotherapy followed by RC from 2004-2014 in the NCDB. The associations of clinicopathologic features with overall survival (OS) were evaluated using Cox regression, and a simplified risk score was developed.RESULTS:A total of 491 patients received chemotherapy followed by RC. Median age was 62 years, and the median number of lymph nodes removed was 15 (IQR 8, 24). At RC, 10% of patients were ypT0, and 35% were ypN0. Over a median follow-up of 18.7 (IQR 8, 39) months, 160 patie...