PRETERM EYLEM TEDAVİSİNDE NİFEDİPİN'İN ETKİNLİĞİ

Objective: Our aim is to determine the effectiveness of nifedipine as a tocolytic in woman with preterm labor and to determine the factors to prolong pregnancy.Material and Methods: 112 woman in 24-37 weeks’ gestation who were admitted to Suleymaniye Birth And Women Health Education And Research Hospital and hospitalized to take nifedipine as tocolytic from january 2007 to 2011 december were added to our study. Partisipants were diveded into two groups according to their delay in timing of birth: Less than seven days and lonfer than seven days. These groups were compared on the basis of their demographical feature,nenotal and maternal followup results.Results: There were no statistically difference in between two groups for age, body mass index, gravidity, parity, cervical lenght at time of admission, Bishop score and the mean gestational age (p< 0,05). In 69,7% of patients delivery was prolonged for longer than 7 days and 32 patients gave birth before 34 weeks. 21 of these 32 patients (65,6%) was in the first group in which delivery was prolonged for 7 days or less (p: 0,021). In the other group as compared for mode of delivery cesarean section was statistically low (61,8% vs 34,6% p: 0,008). Neonatal complications as respiratory distress syndrome need for intensive care unit was statistically high in less than 7 days prolonged for gestation group (p: 0,017, p: 0,036 respectively). Conclusion: Use of nifedipine is pervaded as a tocolytic since it has minimal adverse effects on fetal and maternal systems with its simple oral usage, but there is no satisfactory placebo clinical trials on ideal medication.