Postmastectomy Radiotherapy with and Without Reconstruction

The role of radiotherapy after mastectomy, postmastectomy radiotherapy (PMRT), in women with node-positive or high-risk node-negative breast cancer has evolved over the last several decades since the publication of the randomized trials from the British Columbia Cancer Agency and the Danish Breast Cancer Cooperative Group [1–3]. These trials were the first trials using modern radiation techniques and systemic therapy to demonstrate that PMRT not only reduced locoregional recurrences (LRRs) but also improved survival. The impact of PMRT on local control and overall survival has been further supported by the results of the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) meta-analysis [4, 5].