Association between metabolic syndrome and colorectal carcinoma based on a case-control study

Objective To evaluate the association between metabolic syndrome and colorectal carcinoma. Methods A total of 900 patients with colorectal carcinoma from 2013 to 2016 in Qianfoshan Hospital Affiliated to Shandong University were selected as the case group and 1 774 non-colorectal carcinoma participants from health management center as the control group. Logistic regression model was used to identify the relationship between metabolic syndrome and colorectal carcinoma. Results Compared with the controls (27.0%), metabolic syndrome was more prevalent among cases (35.4%). The difference was statistically significant (χ2=20.33, P<0.01). Multivariate logistic regression analyses showed that metabolic syndrome as an entity increased colorectal carcinoma risk (OR=1.38, 95%CI: 1.08-1.75, χ2=17.68, P<0.01). Subjects with 2 and 3 or more components of the metabolic syndrome had an increased risk of colorectal carcinoma, and the ORs of colorectal carcinoma were 1.37 and 1.60, respectively. Gender-specific patterns were also observed in the association between metabolic syndrome, component and colorectal carcinoma (χ2=5.40, P=0.02; χ2=8.66, P<0.01). Conclusion Metabolic syndrome is associated with the occurrence of colorectal carcinoma. An increasing trend in risk of colorectal carcinoma with the number of metabolic syndrome components is observed. Key words: Metabolic syndrome X; Colorectal neoplasms; Case-control studies