Protective effect of Panax notoginseng saponins on rat model of hemorrhagic shock and resuscitation phase

AIM To study the effect of Panax notoginseng saponins on an inflammatory response induced by hemorrhagic shock and resuscitation.METHODS The involved experimental rats model of hemorrhagic shock for 75 min and reperfusion of ringer's solution up to 90% blood volume were created.One hundred male Wistar rats were randomly divided into five groups,control group,model group(hemorrhagic shock/resuscitation,HS/R) and Panax notoginseng saponins low,middle and high dose treatment groups(50,100,200 mg/kg).The does of Panax notoginseng saponins was injected at 70 min after hemorrhagic shock.Arterial oxygen pressure,mean arterial pressure and heart rate were recorded at hemorrhagic resuscitation phase.Then TNFα,IL-1β,endotoxin,malondialdehyde(MDA),superoxide dismutase(SOD) and myeloperoxidase(MPO) were tested in 30 min and 2 h after resuscitation.RESULTS Mean arterial pressure and arterial oxygen pressure in Panax notoginseng saponins treatment groups increased significantly(P0.05).The inflammatory indexes in Panax notoginseng saponins treatment groups were lower than those in the model group in 30 min and 2 h.CONCLUSION Pretreatment of Panax notoginseng saponins before fluid resuscitation shows a beneficial effect on the hemodynamic stabilization through anti-inflammation and anti-oxidase in HS/R rat model.