Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation.

Hannah M. Campbell,Ann P. Quick,Issam Abu-Taha,David Y. Chiang,Carlos F. Kramm,Tarah A. Word,Sören Brandenburg,Mohit Hulsurkar,Katherina M. Alsina,Hui-Bin Liu,Brian Martin,Dennis Uhlenkamp,Oliver M. Moore,Satadru K. Lahiri,Eleonora Corradini,Markus Kamler,Albert J. R. Heck,Stephan E. Lehnart,Dobromir Dobrev,Xander H.T. Wehrens

Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation.

2020

Background: Enhanced diastolic calcium (Ca2+) release via ryanodine receptor type-2 (RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic reticulum (SR) Ca2+ leak...

Keywords:

Diastole
Phosphorylation
Internal medicine
Medicine
Endoplasmic reticulum
Cardiology
Atrial fibrillation
Endocrinology
Calcium
Ryanodine receptor
Ion channel
Ryanodine receptor 2

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