Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer.

Abu Shadat Mohammod Noman,Rashed R. Parag,Muhammad I. Rashid,M. Z. Rahman,Ali Asgar Chowdhury,Afrin Sultana,Chandsultana Jerin,Ayesha Siddiqua,Lutfur Rahman,Afsana Shirin,Junayed Nayeem,Reaz Mahmud,Sonam Akther,Rajib Kumar Shil,Ikram Hossain,Sharmin Alam,Arfina Chowdhury,Shabnam B. Basher,Abul Hasan,Shammy Bithy,Jannatul Aklima,Mizanur Rahman,Nabila Chowdhury,Tahmina Banu,Bedri Karakas,Herman Yeger,Walid Farhat,Syed S. Islam

Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer.

2020

Background:Sonic hedgehog (Shh) and Nrf2 play a critical role in chemotherapeutic resistance. These two genes have been found to be dysregulated in head and neck squamous cell carcinomas (HNSCC). T...

Keywords:

Pathology
Head and neck cancer
Cell
Cisplatin
Cancer research
Medicine
Sonic hedgehog
HPV Negative
disease free survival
head and neck
in patient

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