Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization

Marc-Antoine de La Vega,Jocelyne Piret,Bryan D. Griffin,Chantal Rhéaume,Marie-Christine Venable,Julie Carbonneau,Christian Couture,Raquel Das Neves Almeida,Roland R. Tremblay,Kelly Grace Magalhães,Young K. Park,Christine Roberts,Joel N. Maslow,Niranjan Y. Sardesai,J. Joseph Kim,Kar Muthumani,David B. Weiner,Gary P. Kobinger,Guy Boivin

Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization

2019

Marc-Antoine de La Vega
Jocelyne Piret
Bryan D. Griffin
Chantal Rhéaume
Marie-Christine Venable
Julie Carbonneau
Christian Couture
Raquel Das Neves Almeida
Roland R. Tremblay
Kelly Grace Magalhães
Young K. Park
Christine Roberts
Joel N. Maslow
Niranjan Y. Sardesai
J. Joseph Kim
Kar Muthumani
David B. Weiner
Gary P. Kobinger
Guy Boivin

Background Zika virus (ZIKV) infection has been associated with prolonged viral excretion in human semen and causes testicular atrophy and infertility in 10-week-old immunodeficient mice.

Keywords:

Virology
Zika virus
Infertility
Fertility
Male infertility
Medicine
Asymptomatic
Physiology
Immunology
Viremia
Testicular atrophy
Semen
Vaccination

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