Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study
2009
Background
Dioxins and related compounds are suspected of causing neurological disruption. Epidemiological studies indicated that exposure to these compounds caused neurodevelopmental disturbances such as learning disability and attention deficit hyperactivity disorder, which are thought to be closely related to dopaminergic dysfunction. Although the molecular mechanism of their actions has not been fully investigated, a major participant in the process is aryl hydrocarbon receptor (AhR). This study focused on the effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on the regulation of TH, a rate-limiting enzyme of dopamine synthesis, gene expression by AhR.
Keywords:
- Environmental health
- Aryl hydrocarbon receptor
- Tyrosine hydroxylase
- Gene expression
- Reporter gene
- Dopamine
- Medicine
- Attention deficit hyperactivity disorder
- Neurotoxicity
- Endocrinology
- Dopaminergic
- Internal medicine
- Response element
- Molecular biology
- Electrophoretic mobility shift assay
- Regulatory sequence
- Toxicology
- Transactivation
- Correction
- Source
- Cite
- Save
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