Measurement of Myocardial Extracellular Volume Fraction From Iodine Density Images Using Single-source, Dual-energy Computed Tomography: A Feasibility Study.

Objective The aims of this study were to develop and validate an iodine density method for the quantification of myocardial extracellular volume (ECV) fraction using single-source, dual-energy computed tomography. Methods Extracellular volume measurements were carried out in 40 subjects (20 patients with heart failure, 20 control subjects) using single-source, dual-energy computed tomography. Subtraction-derived ECVs (subECVs) were computed by subtracting precontrast from delayed images. Iodine density-derived ECVs (iECVs) were calculated from iodine density images obtained from delayed images. Iodine density-derived ECVs were compared with reference subECVs. Results A strong correlation (r = 0.896, P Conclusions Extracellular volume analysis using iodine density is a useful tool for the noninvasive quantification of ECV in myocardial diseases.