Stereochemistry and X-ray Crystal Structure of$lsquoPyrrole Trimer’: Synthesis ofcis-2,5-Di(pyrrol-2-yl)pyrrolidine (cis PyrroleTrimer) and X-ray Crystal Structure ofcis-1-(4-Methylphenylsulfonyl)-2,5-di(pyrrol-2-yl)pyrrolidine (Monotosyl cis Pyrrole Trimer)
1997
Pyrrole reacts with aqueous hydrochloric acid at 0
°C to give a 2:1 mixture of trans(1) and
cis(2) isomers of 2,5-di(pyrrol-2-yl)pyrrolidine which,
by conversion into a mixture of the corresponding monotosyl
derivatives then exposure of these to sodium hydroxide under
phase-transfer conditions, are converted completely into the
tosyl derivative (4) of the cis isomer, from which the
tosyl group can be cleaved to produce pure cis
$lsquopyrrole trimer$rsquo.
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