Electrospun zein/PCL fibrous matrices release tetracycline in a controlled manner, killing Staphylococcus aureus both in biofilms and ex vivo on pig skin, and are compatible with human skin cells

Purpose To investigate the destruction of clinically-relevant bacteria within biofilms via the sustained release of the antibiotic tetracycline from zein-based electrospun polymeric fibrous matrices and to demonstrate the compatibility of such wound dressing matrices with human skin cells.