Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines.
2001
The synthesis of allylic amine libraries derived from olefin templates is described. The two-step, solution phase reaction sequence consists of amination of the template followed by Suzuki coupling and expedited purification via ion exchange chromatography. The methodology has been used to synthesize a 1344-member allylic amine library.
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