Correlation between plasma microRNA and microglobulin and acute myocardial infarction

Objective To investigate the correlation in plasma microRNA, microglobulin and acute myocardial infarction. Methods A retrospective study was performed on 90 cases of patients with acute myocardial infarction who were admitted from May 2014 to May 2016.The 90 patients were divided into the observation group, another 90 volunteers were divided into the control group.The levels of microRNA and microglobulin in plasma circulation were detected by fluorescence quantitative PCR assay and the immune turbidimetry test in both groups. Results In the observation group of patients, plasma circulation related microRNA-208, microRNA-241, microRNA-423 and microRNA-499, the expression levels were significantly higher than those of the control group(P<0.05); α1-microglobulin and β2-microglobulin were significantly higher than those of the control group(P<0.05), and the differences were statistically significant(P<0.05). Conclusion The plasma circulation related microRNA in patients with acute myocardial infarction has significantly high expression, the expression level of the microglobulin also shows significant abnormal state; the expression level of plasma circulation related microRNA and microglobulin has significant correlation with the incidence of acute myocardial infarction. Key words: MicroRNA; Microglobulin; Acute myocardial infarction; Fluorescence quantitative PCR method; Immune turbidimetry