Mitomycin-Induced Pulmonary Veno-Occlusive Disease in a Patient with Carcinoma of the Breast

Introduction Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH). Despite being described over 70 years ago, PVOD is poorly understood and difficult to diagnose. PVOD is associated with connective tissue disorders, bone marrow transplantation, infection, sarcoidosis, and exposure to chemotherapeutic agents including mitomycin, bleomycin, and carmustine. It is characterized by intimal and medial fibrosis of the pulmonary venules and veins of the lobular septa. We present a case of a patient with PVOD receiving mitomycin C for the treatment of breast cancer.