Alterung und Lichtalterung von Keratinozyten und Melanozyten

An overview of keratinocyte and melanocyte function is provided. The processes of cutaneous aging and photoaging are defined, and age-associated modulations in gene expression are described. The changes in keratinocytes and melanocytes that occur with skin aging and photoaging and the characteristics of chronologically aged vs. photoaged skin are delineated. Mutations that are found in malignant and premalignant tumours of epidermal origin are described.