A comparative immunogenicity-reactogenicity dose-response study of influenza vaccine

This study examined the immunogenic and reactogenic responses of influenza vaccine in 29 healthy nonallergic adults at three vaccine dosages: 0.5 mL, 0.1 mL, and 0.05 mL. Although the results of the present study suggest that vaccine dilution results in a decrease in adverse reactions, there is also the risk of decreased protective immunity with this procedure and therefore the practice should not be condoned