[Performance of computer-assisted imaging system in detection of squamous intraepithelial lesion of uterine cervix].

Objective To evaluate the performance of computer-assisted imaging system in the detection of cervical squamous intraepithelial lesion and quality-assurance.Methods Manual PAP screening (n =140 580) and image-assisted screening (n =32 885) were compared for the detection rates of squamous cell abnormalities,the atypical squamous cells (ASC) to squamous intraepithelial lesion (SIL) ratio,the positive rates of high risk human papillomavirus (HR-HPV) test in the case of atypical squamous cells of undetermined significance (ASC-US),and the correlation between cytopathology and histopathology.Results Compared with manual screening,computer-assisted imaging system showed increased overall positive detection by 0.32％,decreased detection of ASC by 0.21％,increased detection of low-grade squamous intraepithelial lesion (LSIL) by 0.22％,increased detection of high-grade squamous intraepithelial lesion or worse (HSIL) by 0.31％,and decreased ASC to SIL ratio from 2.59 to 1.60.Computer-assisted imaging system did not change the HR-HPV positive rate of the patients who were ASC-US,or the coincidence rate between cytopathology and histopathology.Moreover,the productivity of the laboratory operation increased 58.33％.Conclusion Computer-assisted imaging system significantly increases the overall positive detection rate of cervical SIL,improves accuracy and work efficiency of screening,decreases the ASC/SIL rate,and strengths the quality-assurance of laboratory testing. Key words: Uterine cervical diseases;  Papillomavirus, human;  Diagnosis, computer-assisted