Epilepsy in Patients with Multiple Sclerosis: Radiological‐Clinical Correlations

Summary: Purpose: To determine potential mechanisms of epilepsy in patients with multiple sclerosis (MS). Methods: Among 402 patients with clinically and radiologically defined MS, including de novo cases, presenting to the Neurology Service, University Hospital of Dijon, we identified 17 with epileptic seizures (4.25%). Among them, the percentage with partial seizures (50%) was greater than that in the reference population. Results: In most of the patients with MS, plaques were localized in the frontal region, associated with frontal and callosal atrophy, a frontal syndrome, and severe disability status (as assessed by a standard scale). Magnetic resonance imaging (MRI) showed numerous subcortical plaques. Seizures generally were well controlled with antiepileptic drugs (AEDs). Conclusions: Our data suggest that the subcortical plaques of MS underlie seizure activity in patients with MS and epilepsy.