Donor Lymphocyte Infusion Vs. Second Allogeneic HCT In Relapsed AML After Allografting: A Landmark Analysis From The Acute Leukemia Working Party Of EBMT

Background Best management of AML relapsing after allogeneic HCT is controversial. While enrollment in clinical trials is ideal, such option would generally exclude these patients from participation. Accordingly, offering donor lymphocyte infusion(s) (DLI) or a second allogeneic (2nd-allo) HCT are commonly pursued. Methods Patients (pts), disease, and treatment characteristics related to 1st-first allograft are shown ([Table 1][1]). We compared outcomes of allografted pts receiving DLI (n=321, male=57%) or 2nd-allo (n=297, male=54%) within 100 days from relapse/progression after 1st-allo HCT between 01/2000-12/2011. Pts were not in remission at time of DLI or 2nd-allo and the majority of DLI-treated received 1 dose [1 dose=220, 2 doses=68, ≥3 doses=33). Forty-six pts received a 2nd-allo after DLI. PBSC was more commonly used for the 2nd-allo (PBSC=277, BM=14, CB=4, unk=2). Pts receiving DLI were older [50 (18-71) vs. 43 (18-72) yrs, p<0.0001] and DLI was offered sooner [26 (1-100) vs. 44 (1-99) days, p<0.0001]. View this table: Table 1 Patient, disease, and treatment characteristics (1st allo-HCT) Results Median F/U (all pts) from time of post allo-HCT relapse was 17 (0.3-125) months. Two-year overall survival (OS) from intervention (DLI or 2nd-allo) was poor regardless of modality offered (DLI=17±2% vs. 2nd-allo=13±2%, p=0.14). However, 2-year OS from relapse (intervention as time-dependent variable after relapse) favored DLI [HR=1.35 (95%CI: 1.13, 1.61, P=0.001]. Multivariate analyses (Cox proportional hazard model) to evaluate OS from time-of-relapse or from time-of-intervention (DLI or 2nd-allo) were performed. OS (from relapse) was worse when a 2nd-allo was offered as the preferred choice [HR=1.28 (95%CI:1.05, 1.56), p=0.01]. Also, the following variables at time of 1st-allo HCT were associated with worse OS (from relapse): age>46 yrs [HR=1.27 (95%CI:1.04, 1.55), p=0.02], use of MRD [HR=1.34(95%CI:1.11, 1.62), p=0.002], relapse 33 days [HR=0.79 (95%CI:0.65, 0.96), p=0.01], worse for age>46 yrs [HR=1.25 (95%CI:1.03, 1.53), p=0.03], URD [HR=1.40 (95%CI:1.15, 1.69), p=0.0006], relapse <6 months from allografting [HR=0.50 (95%CI:0.41, 0.60), p<0.0001], presence of grade II-IV acute GVHD before relapse [HR=1.34 (95%CI:1.04, 1.73), p=0.03], and PBSC as cell source [HR=1.39 (95%CI:1.03, 1.86), p=0.03] Conclusion Notwithstanding poor outcomes whether DLI or a 2nd-allo is offered, especially when relapse occurs within ≤ 6 months, a preliminary multivariate analyses shows that DLI use, younger age, MRD, lack of prior GVHD, and relapse > 6 months from allografting were associated with better OS. Further analysis on factors affecting physician’s choice of modality and prior cytoreductive therapy(ies) is warranted to shed light on the complex decision making process for post-allograft relapse management. Disclosures: No relevant conflicts of interest to declare. [1]: #T1