[Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages].

Objective To analyze Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages.Methods This study involved 170 patients with HIV/AIDS and 34 HIV-negative patients.All the patients underwent upper endoscopy and antral gastric biopsy to determine the status of Helicobacter pylori infection using aniline red staining and rapid urease test.The patients with HIV/AIDS were stratified based on CD4+T lymphocyte counts and clinical setting into asymptomatic HIV infection(A1,A2) group,symptomatic HIV infection(B1,B2) group and AIDS(A3,B3,C1-3) group.Results The prevalence of Helicobacter pylori infection in HIV/AIDS patients was 16.5%(28/170),and in the 3 groups classified,the infection rates were 23.4%(11/47),14.0%(8/57),and 13.6%(9/66),respectively;the infection rate was 47.1%(16/34) in the control group.Helicobacter pylori infection rate in the gastric mucosa of the patients with HIV/AIDS in different clinical stages was significantly lower than that of the control group(P0.05);the infection rates in symptomatic HIV-infected(B1,B2) group and AIDS(A3,B3,C1-3) group were significantly lower than that in asymptomatic HIV-infected(A1,A2) group(P0.05).Conclusion The low Helicobacter pylori infection rate in HIV/AIDS patients may result from severe immunodeficiency in the gastric mucosa.